IMMUNOASSAYS EXHIBITING REDUCED CROSS-REACTIVITY WITH HYDROPHOBIC DRUG ANALYTE METABOLITES

摘要

The present disclosure provides among other things immunoassays exhibitin g reduced cross-reactivity with analyte metabolites. Additionally, the prese nt disclosure provides diagnostic immunoassays to determine the concentratio n or level in a test sample of a hydrophobic drug that metabolizes in vivo o r in vitro to form cross-reacting metabolites wherein cross-reactivity with such metabolites of the drug analyte is reduced. In particular, the disclosu re provides such immunoassays where the hydrophobic drug is an immunosuppres sant drug such as cyclosporine A.