HETEROARYL-HETEROARYL COMPOUNDS AS CDK INHIBITORS FOR THE TREATMENT OF CANCER, INFLAMMATION AND VIRAL INFECTIONS

摘要

The present application describes organic compounds of formula (I), wherein m is 0 or 1; n is 0 or 1; A1, A2, A3 and A4 are each, independently, C, C(H) or N; that are useful for the treatment and therapies for protein kinase-associated disorders. They are in particular useful in the treatment or prevention on amelioration of one or more symptoms of cancer, inflammation, cardiac hypertrophy, and HIV by modulating the activity of protein kinases, such as CDK1, CDK2, CDK3, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, and combinations thereof.