INHIBITION OF LI EXPRESSION IN MAMMALIAN CELLS

摘要

The present invention is directed toward compositions and methods involving the inhibition of li expression in cells for the purpose of altering antigen presentation pathways. More specifically, disclosed are compositions and methods which relate to MHC class II molecule presentation of antigenic epitopes which, under normal circumstances, would not be presented in association with MHC class II molecules. The invention relates to presentation in cells which normally express MHC class II molecules, as well as cells which can be induced to express MHC class II molecules. Embodiments relating to RNA interference of li are specifically disclosed.