发明名称 METHOD OF FORMING AN AEROSOL FOR INHALATION DELIVERY
摘要 <p>The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000 ~C/s , thereby forming an vapor; and, (b) allowing the vapor to cool, thereby formi ng an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, where in the coated composition is in the form of a film less than 10 .theta. thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is us ed in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapo r to cool, thereby forming an aerosol, which is used in inhalation therapy.</S DOAB></p>
申请公布号 CA2447354(C) 申请公布日期 2008.12.02
申请号 CA20022447354 申请日期 2002.05.13
申请人 ALEXZA MOLECULAR DELIVERY CORPORATION 发明人 MCKINNEY, JEFFREY A.;MYERS, DANIEL J.;QUINTANA, REYNALDO J.;HALE, RON L.;HODGES, CRAIG C.;LLOYD, PETER M.;SONG, SOONHO;ROGERS, DANIEL D.;WENSLEY, MARTIN J.;RABINOWITZ, JOSHUA D.;MUFSON, DANIEL
分类号 A61K9/12;A61K9/72;A61K9/00;A61K9/16;A61K31/4468;A61M11/00;A61M11/04;A61M15/00;A61M16/00;A61P23/00;B05B7/16;B05B17/04 主分类号 A61K9/12
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