Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido [1,2-a] pyrimidin-4-one derivatives

摘要

Disclosed is a substituted-pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof wherein R4 represents a C1-2 perhalogenated alkyl group or a C1-3 halogenated alkyl group; and the rest of the substituents are disclosed within the specification. Also disclosed is the GSK3beta (glycogen synthase kinase 3beta) inhibitor activity of the above compound and hence the use of the above compound for the preparation of a medicament for preventive and/or therapeutic treatment of a neurodegenerative disease.