DAA PERIPHERAL BENZODIAZEPINE RECEPTOR LIGAND FOR CANCER IMAGING AND TREATMENT

摘要

Peripheral Benzodiazepine Receptor (PBR) is an attractive target for tumor imaging and treatment due to its upregulation in numerous cancer cell types. DAAl 106 is a selective PBR ligand with high binding affinity. Aspects of the present invention are series of functionaJized DAAl 106 analogs, which can be conjugated to a variety of signaling and treatment moieties, and are widely applicable in PBR targeted molecular imaging and drug delivery.