POLYMORPHISMS IN THE HUMAN XBP-1 GENE ARE ASSOCIATED WITH INFLAMMATORY BOWEL DISEASE

摘要

The instant invention is based, at least in part, on the finding that XBP-I plays a role in intestinal inflammation that resembles inflammatory bowel disease and that a single SNP in the 5' untranslated region of the human XBPl gene is significantly associated with IBD predicting a direct role for XBPl in the pathogenesis of this disease. Accordingly, the present invention provides methods for detecting at least one SNP in the human XBP-I gene as well as methods to determine the predisposition of a human subject to develop inflammatory bowel disease.