| 摘要 |
<p>(A) Cpds. of general formula (I) R' = (1-5C)alkyl or (is not >7C) cycloalkyl or cycloalkenyl (B) Acid addn. salts of I. Oral and parenteral hypoglycaemics. Dose 100-500 mg/d. BrCN (10.6 g.) was added to N'-(2-butylamino-ethyl)-N4-acetylsulphanilamide (31.3 g.) in 2N-NaOH (100 ml), stirred 30 mins. at 20-30 deg., filtered, and recryst. from D.M.F., giving N-acetyl-I, m.p.243-4 deg. This (33.8 g.) was heated 1 h. at 80 deg. in 2N-HCl (100 ml), cooled to 20 deg., basified with 2N-NaOH, filtered, washed, and recryst. from EtOH, giving I, m.p.179-181 deg.</p> |
