IMMUNOGLOBULIN ASSOCIATED CELL-SURFACE DETERMINANTS IN THE TREATMENT OF B-CELL DISORDERS
摘要
The present invention provides methods, compositions and vaccines for specifically targeting immunoglobulin associated cell-surface determinants that are not shed into the blood of a host. In some cases, the immunoglobulin associated cell-surface determinants will be involved in various B-cell disorders. The methods involve administering an IACSD targeting element to a B-cell. The method can employ treating an individual with a B-cell associated disorder by administering an effective amount of an IACSD targeting preparation. The compositions include isolated antibodies where the antibodies associate with an immunoglobulin associated cell-surface determinants. The invention also includes vaccines that immunize against immunoglobulin associated cell-surface determinants.
申请公布号
WO2007131129(A3)
申请公布日期
2008.11.27
申请号
WO2007US68174
申请日期
2007.05.03
申请人
GUTHRIE FOUNDATION FOR EDUCATION & RESEARCH;WELT, SYDNEY;KOSTYAL, DAVID, A.