发明名称 |
Modified Proteins, Designer Toxins, and Methods of Making Thereof |
摘要 |
The present invention concerns methods of reducing the antigenicity of a proteinaceous compound while maintaining the compounds biological activity, as well as proteinaceous compositions with biological activity but reduced antigenicity. These methods and compositions have significant benefits to a subject in need of such compounds and compositions. Also included are modified toxin compounds that are truncated and/or possess reduce antigenicity. Such designer toxins have therapeutic, diagnostic, and preventative benefits, particularly as immunotoxins. Methods of treating cancer using these immunotoxins are provided. |
申请公布号 |
US2008292544(A1) |
申请公布日期 |
2008.11.27 |
申请号 |
US20070856606 |
申请日期 |
2007.09.17 |
申请人 |
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发明人 |
ROSENBLUM MICHAEL G.;CHEUNG LAWRENCE |
分类号 |
A61K51/00;G01N33/53;A61K35/76;A61K38/00;A61K38/17;A61K39/395;A61P1/00;A61P1/02;A61P1/16;A61P1/18;A61P5/00;A61P7/00;A61P9/00;A61P11/00;A61P13/08;A61P13/12;A61P15/00;A61P17/00;A61P19/08;A61P25/00;A61P27/02;A61P31/00;A61P35/00;A61P35/02;A61P37/02;C07K14/00;C07K14/415;C07K14/435;C07K16/30;C07K16/40;C07K19/00;C12N5/06;C12N9/00;C12N15/09;C12N15/29;C12P21/00 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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