发明名称 |
6-[(Substituted)phenyl]triazolopyrimidines as anticancer agents |
摘要 |
This invention relates to certain 6-[(substituted)phenyl]triazolopyrimidine compounds or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof. The present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof. |
申请公布号 |
ZA200602387(B) |
申请公布日期 |
2008.11.26 |
申请号 |
ZA20060002387 |
申请日期 |
2006.03.23 |
申请人 |
WYETH HOLDINGS CORPORATION |
发明人 |
ZHANG, NAN;NGUYEN, THAI HIEP;TONG, WEI;AYRAL-KALOUSTIAN, SEMIRAMIS;WU, YANZHONG |
分类号 |
A61K;A61P;A61P35/00;A61P35/04;C07D;C07D487/04 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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