发明名称 |
LIVE ATTENUATED BORDETELLA STRAINS AS A SINGLE DOSE VACCINE AGAINST WHOOPING COUGH |
摘要 |
A mutated Bordetella strain comprising at least a mutated ptx gene, a deleted or mutated dnt gene and a heterologous ampG gene is provided. The attenuated mutated Bordetella strain can be used in an immunogenic composition or a vaccine for the treatment or prevention of a Bordetella infection. Use of the attenuated Bordetella strain for the manufacture of a vaccine or immunogenic composition, as well as methods for protecting mammals against infection by Bordetella are also provided. |
申请公布号 |
EP1994139(A1) |
申请公布日期 |
2008.11.26 |
申请号 |
EP20070711815 |
申请日期 |
2007.03.07 |
申请人 |
INSTITUT PASTEUR DE LILLE;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) |
发明人 |
LOCHT, CAMILLE;MIELCAREK, NATHALIE;DEBRIE, ANNE-SOPHIE;RAZE, DOMINIQUE;BERTOUT, JULIE |
分类号 |
C12N1/36;A61K39/00;A61K39/02;A61K39/10 |
主分类号 |
C12N1/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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