摘要 |
<p>The present invention refers to a pharmaceutical composition for a local anesthetic gel intended for topical use in dental procedures. The pharmaceutical composition comprises a pharmaceutically effective amount of at least one anesthetic and at least one gelling agent, said composition having a minimum viscosity of 30 Pa. s, when subjected to a temperature ranging from 5°C to 50°C. The subject invention allows a higher penetration of the anesthetic through a stable viscosity which maintains the drug for a longer time and at a higher concentration on the action site, increasing anesthesia time, reducing its toxicity, and restricting the action of the drug to the application site.</p> |
申请人 |
UNIVERSIDADE ESTADUAL DE CAMPINAS - UNICAMP;ROTOLO SILVA, ANDRE LUIZ;MONTAN, MICHELLE FRANZ;GROPPO, FRANCISCO CARLOS;VOLPATO, MARIA CRISTINA;RANALI, JOSE;FRACETO, LEONARDO FERNANDES;DE PAULA, ENEIDA |
发明人 |
ROTOLO SILVA, ANDRE LUIZ;MONTAN, MICHELLE FRANZ;GROPPO, FRANCISCO CARLOS;VOLPATO, MARIA CRISTINA;RANALI, JOSE;FRACETO, LEONARDO FERNANDES;DE PAULA, ENEIDA |