The inventors have succeeded in discovering that the p75 neurotrophin receptor (p75NTR) is directly involved in the degradation of cAMP via interaction of its intracellular domain with phosphodiesterase 4A4/5 (PDE4A4/5). Provided herein are methods and compositions for the treatment of conditions of PDE4A4/5 and p75NTR expression (such as pulmonary disease and nerve regeneration) by blocking the interaction of PDE4A4/5 and p75NTR, as well as methods for the screening of agents useful in such applications.
申请公布号
WO2008022153(A3)
申请公布日期
2008.11.20
申请号
WO2007US75934
申请日期
2007.08.14
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;AKASSOGLOU, KATERINA;HOUSLAY, MILES, D.;CHAO, MOSES, V.
发明人
AKASSOGLOU, KATERINA;HOUSLAY, MILES, D.;CHAO, MOSES, V.