IDENTIFICATION OF COMPOUNDS THAT PROTECT AGAINST AMYLOID DISEASES

摘要

Compositions and methods for inhibiting protein aggregation and aggregation- mediated proteotoxicity are provided. Compositions include at least one of a flavone, a biguanide, a furanoflavonoid, 5-Aminoimidazole-4-carboxamide 1-ß-D- ribofuranoside, trimethadione, morin, and combinations thereof. The compositions can be used in conjunction with other compounds known to inhibit protein aggregation to enhance their activities. The invention further provides methods for identifying compounds that inhibit protein aggregation. The methods include the expression of a ß-amyloid peptide and determining the effect of a test compound on paralysis and/or protein aggregation.