发明名称 |
Hepatocyte Bioreactor System For Long Term Culture of Functional Hepatocyte Spheroids |
摘要 |
A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible.
|
申请公布号 |
US2008286759(A1) |
申请公布日期 |
2008.11.20 |
申请号 |
US20080177017 |
申请日期 |
2008.07.21 |
申请人 |
IN VITRO TECHNOLOGIES, INC. |
发明人 |
BROWN LANIKA A.;SILBER PAUL M.;COWGER NANCY L.;MILLER ANA P.;LI ALBERT P. |
分类号 |
C12Q1/70;C12N5/02;C12N5/071 |
主分类号 |
C12Q1/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|