摘要 |
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer an d other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
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申请人 |
AGOURON PHARMACEUTICALS, INC. |
发明人 |
BENDER, STEVEN LEE;JOHNSON, MICHAEL DAVID;BORCHARDT, ALLEN J.;BRAGANZA, JOHN F.;PALMER, CYNTHIA LOUISE;WALLACE, MICHAEL BRENNAN;LUU, HIEP THE;JOHNSON, THEODORE OTTO JR.;KANIA, ROBERT STEVEN;COLLINS, MICHAEL RAYMOND;REICH, SIEGFRIED HEINZ;TENG, MIN;TEMPCZYK-RUSSELL, ANNA MARIA;CRIPPS, STEPHAN JAMES;HUA, YE;VARNEY, MICHAEL DAVID;THOMAS, CHRISTINE |