摘要 |
<p>The use of dihydropyridine-5-phosphonic acid cyclic propylene ester derivatives of formula (I), a prodrug thereof, or a pharmaceutically acceptable salt of said compound or prodrug in the treatment of cancers, pre-cancerous conditions and other conditions is disclosed, wherein each of R<SUB>1</SUB>-R<SUB>8</SUB> are the same or different, are hydrogen or C<SUB>1</SUB>-C<SUB>6</SUB> alkyl; one of X<SUB>1</SUB> and X<SUB>2</SUB> is nitro while the other is hydrogen; each of Y<SUB>1</SUB> and Y<SUB>2</SUB> may be the same or different, is phenyl which may be substituted by chlorine, fluorine or alkoxy; and m and n are integers from 0-4, a prodrug thereof, or a pharmaceutically acceptable salt thereof.</p> |