NUCLEIC ACID COMPOUNDS FOR INHIBITING MAPK GENE EXPRESSION AND USES THEREOF

摘要

The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing MAPK gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a MAPK mRNA. In addition, the meroduplex may have at least one uridine substituted with a 5-methyluridine, a nucleoside replaced with a locked nucleic acid, or optionally other modifications, and any combination thereof. Also provided are methods of decreasing expression of a MAPK gene in a cell or in a subject to treat a MAPK-related disease.