EUKARYOTIC CELLS EXPRESSING (SID-I) FOR GENE SCREENING

摘要

This invention provides a eukaryotic cell that stably expresses exogenous, ectopic SID-1 to confer enhanced polynucleotide, e.g. siRNA or dsRNA, uptake. Thus, in one aspect, this invention provides a eukaryotic cell which stably expresses exogenous SID-1 polynucleotide and is. The cells stably expressing SID-1 are particularly useful for high throughput screening of gene activity using RNA interference. Methods for producing and using the cells also are provided in this application.