METHOD FOR THE IN VITRO CULTURE OF T CELLS, IN PARTICULAR T CELLS INFILTRATING THE SO-CALLED TIL TUMOURS

摘要

The invention relates to a method for the in vitro culture of T cells, in particular of modified or non-modified T cells infiltrating the so-called TIL tumours, from a tumour or blood sampling of the patient suffering from a tumour, said method successively and at least comprising a step of emergence of the T cells contained in the sampled blood or tumour, a step of stimulation of the T cells resulting from the emergence step, and a step of amplification of the stimulated T cells. The method is characterised in that the stimulation of the T cells is carried out in a closed and partitioned culture vessel.