TNF.ALPHA. GENE EXPRESSION AS A BIOMARKER OF SENSITIVITY TO ANTAGONISTS OF INHIBITOR OF APOPTOSIS PROTEINS

摘要

TNF.alpha. gene expression can be used as a biomarker of a cell's sensiti vity to antagonists of inhibitor of apoptosis proteins (IAPs). Methods of th e invention are useful for screening patients to identify those who could be nefit from administration of an IAP antagonist to treat various malignant or benign tumors, benign proliferative diseases, or autoimmune diseases.