| 摘要 |
A natriuretic peptide drug combination is provided to maintain high an activity of the peptide in vivo using a carrier substance, to increase remarkably a half life in blood and to be usefully used for various peptide drugs. A natriuretic peptide combination, a natriuretic peptide and an immunoglobulin Fc domain are connected through a peptide-free polymer selected from a group consisting of a polyethylene glycol, a polypropylene glycol, an ethylene glycol-propyleneglycol copolymer, a polyoxyethylated polyol, a polyvinyl alcohol, a polysaccharide, a polyvinyl ethyl ether, a biodegradable polymer, a geopolymer, a chitin, a hyaluronic acid and a mixture thereof.
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