VACUOLAR-TYPE (H+)-ATPase-INHIBITING COMPOUNDS, COMPOSITIONS, AND USES THEREOF

摘要

The present invention provides vacuolar-type (H+)-ATPase-inhibiting compounds, compositions thereof, and methods of using them to treat or prevent a condition treatable by the inhibition of a vacuolar-type (H+)-ATPase. The composition of the present invention comprises a compound of the present invention and a carrier. The method of the present invention includes administering a vacuolar-type (H+)-ATPase inhibiting-effective amount of a compound of the present invention. The compound of the present invention has the formula: wherein R¹ and R² are H, saturated or unsaturated alkyl, aryl, R⁶CH₂-, R⁶CO-, or R⁶SO₂-, wherein R⁶ is H, saturated or unsaturated alkyl, or aryl; R³ is H, alkyl, aryl, an oxime, or an oxime methyl ether; the aromatic ring is unsubstituted or substituted; and Z is a contiguous linker comprising a chain of 0 - 10 atoms which, together with the five atoms beginning with the carbon of the aromatic ring in meta-relationship with OR¹ and ending with the carbon directly attached to the alkyl oxygen of the lactone, integrally form a 5 - 17 membered ring; or a pharmaceutically acceptable salt, an ester, or a prodrug thereof.