TRUNCATED VARIANT OF THE MAMMALIAN TARGET FOR RAPAMYCIN (MTOR) PROTEIN
摘要
The invention relates to mTORbeta, a splice form of mTOR, nucleic acids encoding mTOR beta, and antibodies against mTOR beta. The invention also relates to methods of producing mTOR beta and methods of screening for an agent that modulates mTOR beta expression and/or activity. The invention further relates to a method of treating a disease associated with aberrant expression of mTOR beta by administration of an agent that alters mTOR activity and/or expression.
申请公布号
WO2008132494(A1)
申请公布日期
2008.11.06
申请号
WO2008GB01548
申请日期
2008.05.01
申请人
LUDWIG INSTITUTE OF CANCER RESEARCH;UCL BUSINESS PLC;NEMAZANYY, IVAN;PANASYUK, GANA;ZHYVOLOUP, ALEXANDER;WATERFIELD, MICHAEL;GOUT, IVAN
发明人
NEMAZANYY, IVAN;PANASYUK, GANA;ZHYVOLOUP, ALEXANDER;WATERFIELD, MICHAEL;GOUT, IVAN