METHODS FOR THE PREPARATION OF N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE DERIVATIVES

摘要

A process for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenyl butyl)-p-nitrobenzenesulfonylamide derivatives (I) in which a 1-benzyl-2-hyd roxy-3-isobutylamine derivative (II) is reacted with a p-nitrophenylsulfonyl halide (III) in a solvent comprising a secondary or tertiary alcohol.