STABILIZATION OF LIQUID SOLUTIONS OF RECOMBINANT PROTEIN FORFROZEN STORAGE

摘要

The invention relates to a method for stabilizing a bulk solution of reco mbinant protein for frozen storage, which comprises providing a partially-pu rified solution of recombinant protein which has a monovalent salt concentra tion of at least 100 mM, and adding a carbohydrate to said solution in an am ount sufficient that, upon freezing, the solution has a glass transition tem perature of -56 °C or higher.