| 摘要 |
The invention relates to a new and convergent route to small molecule inhibitors of poly(ADP-ribose) polymerase, such as 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino [5,4,3-cd] indol-6-one, via a key Sonogashira coupling reaction and a Cul-promoted indole formation.
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