发明名称 |
ANTIBIOTIC MICROSPHERES FOR TREATMENT OF INFECTIONS AND OSTEOMYELITIS |
摘要 |
Biodegradable microspheres implanted, injected, or otherwise placed totally or partially within the body are capable of near-linear controlled release of an antibiotic for a predetermined period of time for the treatment and prevention of infections involving the body. The microspheres are formed of polylactic-co-glycolic acid (PLGA) and an effective amount of antibiotic sufficient to produce bactericidal levels in body tissues, and may or may not include polyethylene glycol (PEG). The microspheres exhibit near-linear delivery of the antibiotic for at least 4 weeks at levels exceeding the minimum inhibitory concentration (MIC) for organisms commonly found to be the cause of infections. |
申请公布号 |
EP1549246(A4) |
申请公布日期 |
2008.11.05 |
申请号 |
EP20030754460 |
申请日期 |
2003.09.05 |
申请人 |
AMBROSE, CATHERINE G.;CLYBURN, TERRY A.;MIKOS, ANTONIOS G. |
发明人 |
AMBROSE, CATHERINE G.;CLYBURN, TERRY A.;MIKOS, ANTONIOS G. |
分类号 |
A61F2/02;A61K;A61K9/00;A61K9/16;A61K9/26;A61K9/50;A61K31/545;A61K38/14;(IPC1-7):A61F2/02 |
主分类号 |
A61F2/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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