发明名称 |
Polypeptide for the treatment of cancer and a method for preparation thereof |
摘要 |
This invention characterizes the specific peptide fragment derived from specially prepared zinc charged fetuin and a method of preparation thereof, wherein the fragment was found to contain an apoptosis-inducing activity. Specifically, the amino acid sequence of this peptide is His Thr Phe Ser Gly Val Ala Ser Val Glu (SEQ ID NO: 1). The peptide induced apoptosis in LNCaP (prostate cancer) and HT-29 (colon cancer) cells without affecting CCD 18 Co (normal colon) cells. The in vitro tissue culture study demonstrated that the peptide is more potent than the parent molecule (full-length zinc charged fetuin) in inducing apoptosis. The peptide has a LD<SUB>50 </SUB>of 0.3-0.4 muM, while the LD<SUB>50 </SUB>for zinc-charged fetuin is 3-10 muM.
|
申请公布号 |
US7445784(B2) |
申请公布日期 |
2008.11.04 |
申请号 |
US20060409779 |
申请日期 |
2006.04.24 |
申请人 |
AMBRYX BIOTECHNOLOGY, INC. |
发明人 |
TSAI DAVID |
分类号 |
A61K38/00;A61K39/00;A61K38/04;A61K38/10;A61K38/17;A61K49/00;A61P13/08;A61P35/00;A61P35/02;C07K7/00;C07K7/06;C07K14/47;C07K14/71 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|