发明名称 |
METHODS OF PURIFYING CHONDROITINASE AND STABLE FORMULATIONS THEREOF. |
摘要 |
<p>An aspect of the present invention relates to stable formulations of chondroitinase and to methods of purifying chondroitinase. The methods of purifying chondroitinase includes the steps of extracting the enzyme from a cell, separating the chondroitinase from the crude cell extract using cation-exchange chromatography, removing impurities through gel filtration chromatography, and removing endotoxin through an anion-exchange membrane to produce a purified chondroitinase.</p> |
申请公布号 |
MXPA06013345(A) |
申请公布日期 |
2008.10.31 |
申请号 |
MX2006PA13345 |
申请日期 |
2005.05.18 |
申请人 |
ACORDA THERAPEUTICS, INC. |
发明人 |
ANTHONY O. CAGGIANO;ELLIOT A. GRUSKIN;YELENA G. SHEPTOVITSKY;SARAH KASPERBAUER |
分类号 |
A61K38/47;A61K38/00;C12N9/88 |
主分类号 |
A61K38/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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