发明名称 |
Antibody-based fusion protein featured by prolonged residence in a cireculatory system and method of prolonging its residence time in a circulatory system |
摘要 |
Disclosed are methods for the genetic construction and expression of antibody-based fusion proteins with enhanced circulating half-lives. The fusion proteins of the present invention lack the ability to bind to immunoglobulin Fc receptors, either as a consequence of the antibody isotype used for fusion protein construction, or through directed mutagenesis of antibody isotypes that normally bind Fc receptors. The fusion proteins of the present invention may also contain a functional domain capable of binding an immunoglobulin protection receptor. |
申请公布号 |
PL199659(B1) |
申请公布日期 |
2008.10.31 |
申请号 |
PL19990342497 |
申请日期 |
1999.02.24 |
申请人 |
MERCK PATENT GMBH |
发明人 |
GILLIES STEPHEN D.;LO KIN-MING;LAN YAN;WESOLOWSKI JOHN |
分类号 |
C07K19/00;C12N15/09;C07K14/32;C07K14/52;C07K14/53;C07K14/55;C07K14/705;C07K14/73 |
主分类号 |
C07K19/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|