PREVENTION OF NUCLEAR, SOLAR, AND OTHER RADIATION-INDUCED TISSUE DAMAGE

摘要

Inositol hexaphosphate (IP-6) is a polyphosphorylated carbohydrate with potent antioxidant activity to prevent active oxygen species-mediated mutagenesis, cell injury and carcinogenesis IP-6 also activates DNA repair mechanisms Sublethal radiation causes DNA 5 damage through the fonnation of free radicals, reactive oxygen species, and pyrimidine crosslinks leading to cellular proliferation, cell cycle arrest and apoptosis IP-6 and/or inositol and their pharmaceutically acceptable salts and depvatives, including pyrophosphates and citrate derivatives, significantly counteract the harmful effects of radiation, affecting cell cycle progression in a protective manner (more cells in the protective Gl phase) as well as decreasing apoptosis and caspase-3 activation Vanous salts of IP-6 are used with 15 comparable efficacy and the combination of IP-6 + inositol affords the best protection against radiation-induced cell injury Thus IP-6 and inositol are effective agents for protection against nuclear, solar and other radiation injuries.