发明名称 |
HISTONE DEACETYLASE INHIBITORS |
摘要 |
Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group or a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, genetic disorders, e.g. Huntington's disease and spinal muscular atrophy and genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy.
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申请公布号 |
WO2008011074(A3) |
申请公布日期 |
2008.10.30 |
申请号 |
WO2007US16313 |
申请日期 |
2007.07.19 |
申请人 |
ERRANT GENE THERAPEUTICS, LLC;LAN-HARGEST, HSUAN-YIN;KAUFMAN, ROBERT, J.;WIECH, NORBERT, L. |
发明人 |
LAN-HARGEST, HSUAN-YIN;KAUFMAN, ROBERT, J.;WIECH, NORBERT, L. |
分类号 |
A61K31/19;A61K31/16;A61K31/165;A61K31/20 |
主分类号 |
A61K31/19 |
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