发明名称 |
P53 BINDING T CELL RECEPTOR MOLECULES |
摘要 |
The invention provides T-cell receptor (TCR) molecules comprising a Valpha chain and a Vbeta chain that bind peptides derived from the p53 protein, preferably, the human p53 protein. The TCR molecules include both heterodimeric molecules and single chain molecules which specifically bind a sequence preferably spanning about amino acid positions 264-272 of the p53 protein displayed in the context of an HLA molecule, preferably, HLA-A2.1. Also disclosed are methods for making and using such TCR molecules. The invention has a wide spectrum of useful application including therapeutic uses and use in the detection of cells expressing p53 protein.
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申请公布号 |
US2008269113(A1) |
申请公布日期 |
2008.10.30 |
申请号 |
US20020163084 |
申请日期 |
2002.06.05 |
申请人 |
SHERMAN LINDA A;CARD KIMBERLYN F;WEIDANZ JON A;WONG HING C;THOMSON ELIZABETH L |
发明人 |
SHERMAN LINDA A.;CARD KIMBERLYN F.;WEIDANZ JON A.;WONG HING C.;THOMSON ELIZABETH L. |
分类号 |
A61K38/17;C12N15/09;A61K38/00;A61P35/00;C07H21/04;C07K14/715;C07K14/725;C12N1/15;C12N1/19;C12N1/21;C12N5/06;C12N5/10;C12P21/06;C12Q1/04 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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