L-STEPHOLIDINE (L-SPD) DERIVATIVES, PREPARATION METHOD AND USAGE THEREOF

摘要

The invention relates to l-stepholidine (l-SPD) derivant described as general formula (I) and its producing method. Said l-SPD derivatives and pharmacological acceptable salts, crystalline hydrates, solvates thereof have a double pharmacological effects of dopamine receptor D1 agonistic-D2 antagonistic in global cerebra and have a good physicochemical property and oral bioavailability and can be used to prepare the medicine for treating human or animal nervous system diseases, especially for schizophrenosis and other dopamine receptor correlated nervous system diseases.