| 摘要 |
PROBLEM TO BE SOLVED: To provide an inexpensive and efficient method for producing 4-cyanocyclohexane-1-carboxylic acid useful as an intermediate for producing tranexamic acid. SOLUTION: 4-Cyanocyclohexane-1-carboxylic acid is inexpensively and efficiently produced by irradiating a mixture of 1,4-cyclohexanedicarboxylic acid and 1,4-dicyanocyclohexane with a microwave. 4-Cyanocyclohexane-1-carboxylic acid is catalytically reduced, and the obtained compound is treated with an alkali or ammonia and led to trans-4-aminomethylcyclohexanecarboxylic acid, namely tranexamic acid known as an antiplasmin agent. COPYRIGHT: (C)2009,JPO&INPIT
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