发明名称 |
Nanoparticles for Targeted Delivery of Active Agent |
摘要 |
The present invention concerns a delivery system comprising a polymer-based nanoparticle; and a linker comprising a first portion non-covalently anchored to said nanoparticle, wherein at least part of said first portion comprises a hydrophobic/lipophilic segment embedded in said nanoparticle; and a second portion comprising a maleimide compound exposed at the outer surface of said nanoparticle. In accordance with one embodiment, the delivery system comprises one or more targeting agents, each covalently bound to said maleimide compound. In accordance with yet another embodiment, the delivery system comprises a drug. A specific example for a linker in accordance with the invention is octadecyl-4-(maleimideomethyl)cyclohexane-carboxylic amide (OMCCA).
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申请公布号 |
US2008267876(A1) |
申请公布日期 |
2008.10.30 |
申请号 |
US20060067510 |
申请日期 |
2006.09.20 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY |
发明人 |
BENITA SHIMON;DEBOTTON NIR;GOLDSTEIN DANNY |
分类号 |
A61K49/00;A61K9/14;A61K47/06;A61K47/22;A61K47/26;A61K47/30 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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