METHOD FOR THE PREPARATION OF BETA-METHYLAZETIDINONE

摘要

A method of manufacturing the beta-methyl azetidinone is provided to produce easily the beta-methyl azetidinone without using 4-acetoxyazetidinone which is used to synthesize the beta-methyl. The beta-methyl azetidinone is obligatorily used in order to manufacture carbapenem antibiotics. A compound of a chemical formula 5 is manufactured by reacting a compound of a chemical formula 2 with the cubic aiding agent of a chemical formula 3 or 4 and zinc powders in an organic solvent. The compound of the chemical formula 5 is reacted with the hydrogen peroxide and lithiumhydroxide in the organic solvent. In the chemical formulae, R the tert-butyl dimethylsilyl, R2 phenyl or cyclopropyl, and AUX is the cubic aiding agent.