NITRO-IMIDAZOLE HYPOXIA IMAGING AGENTS

摘要

The present invention relates to novel radioactively labeled bioreducible tracers of Formula (I) useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography.