| 摘要 |
Magnetic resonance imaging contrast agents comprising zinc-containing magnetic metal oxide nanoparticles are provided to increase magnetic susceptibility of metal oxide nano particles and resonance imaging contrast effects of the agent, and improve solution stability and bio-affinity of the agents by inserting zinc into the metal oxide nano particle matrix. A magnetic resonance imaging contrast agent comprises zinc-containing magnetic metal oxide nanoparticles, wherein the metal oxide is represented by the formula(a): MaOb and formula(b): McM'dOe, and the zinc-containing metal oxide is represented by the formula(c): ZnfMa-fOb or formula(d): ZngMc-gM'dOe, which are prepared by replacing the matrix metal of the metal oxide nano particle matrix with zinc or inserting zinc into a hole of the metal oxide nano particle matrix, in which a is 0-16; b is 0-8; c is 0-16; d is 0-16, e is 0-8; f is 0-8, f/(a-f) is 0-10; g is 0-8; g/{(c-g)+d} is 0-10; M is a magnetic metal atom or alloy thereof; M' is an element selected from Group I, Group II, Group XII, Group XIII, Group XIV, Group XV, transition metal element, lanthanide element and actinium element. A hydrodynamic diameter of fluid of the nanoparticles is 1nm to 500mum. |
