MECHANISM TO SIGNAL RECEPTOR-LIGAND INTERACTIONS WITH LUMINESCENT QUANTUM DOTS
摘要
Semiconductor quantum dots are becoming valuable analytical tools for use in biomedical applications. Indeed, their unique properties offer the opportunity to design luminescent probes for imaging and sensing with unprecedented performance. In this context, we have identified operating principles to transduce supramolecular association of complementary receptor- ligand binding pairs into enhancement or suppression in the luminescence of sensitive quantum dots. Thus, complementary receptor-ligand binding pairs can be identified with luminescence measurements relying on our design logic. In fact, we have demonstrated with a representative example that our protocol can be adapted to signal receptor-ligand binding.
申请公布号
WO2008005561(A3)
申请公布日期
2008.10.16
申请号
WO2007US15636
申请日期
2007.07.09
申请人
THE UNIVERSITY OF MIAMI;RAYMO, FRANCISCO, M.;TOMASULO, MASSIMILLIANO;YILDIZ, IBRAHIM
发明人
RAYMO, FRANCISCO, M.;TOMASULO, MASSIMILLIANO;YILDIZ, IBRAHIM