CICLETANINE AND PKC INHIBITORS IN THE TREATMENT OF PULMONARY AND CARDIAC DISORDERS

摘要

Embodiments of the present invention are related to novel therapeutic drugs, drug combinations, and associated methods for treating or preventing pulmonary disease, including pulmonary hypertension, pulmonary fibrosis, asthma and COPD, and heart failure, together with other pulmonary and cardiovascular diseases and their complications. More particularly, aspects of the present invention are related to the use of cicletanine and ruboxistaurin as monotherapies or in combination with other agents for treatment of disease. Cicletanine may be used as pure (+) or (-) enantiomers or as a racemic or non-racemic mixture of those enantiomers.