发明名称 Ethinylated hetero dinucleotide phosphate analoga, method for their manufacture and application thereof
摘要 <p>Ethynylated hetero dinucleoside phosphate analogues (I), are new. Ethynylated hetero dinucleoside phosphate analogues of formula (N 1>-P(=X)(O ->Z +>)-N 2>) (I), are new. X : O or S; Z : H or an acid addition salt; and N 1>, N 2>a nucleoside group, where each of the nucleoside group exhibits a glycoside (or its diverted cyclic) residue and a covalently bonded base residue, the glycoside residue is covalently bonded with the central P atom (oxygen or sulfur link), and at least one of the nucleoside group exhibits an ethynylated glycoside residue. Independent claims are included for: (1) a pharmaceutical agent comprising (I) in a carrier or diluent; and (2) preparation of (I). ACTIVITY : Antimicrobial; Cytostatic; Virucide; Anti-HIV; Antiinflammatory; Hepatotropic. MECHANISM OF ACTION : None given.</p>
申请公布号 EP1980568(A1) 申请公布日期 2008.10.15
申请号 EP20070007635 申请日期 2007.04.13
申请人 EBERHARD KARLS UNIVERSITAET TUEBINGEN 发明人 SCHOTT, HERBERT;LUDWIG, PETER
分类号 C07H21/00;A61K31/7084;A61P35/00 主分类号 C07H21/00
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