发明名称 PROCESS FOR THE PREPARATION OF RAPAMYCIN DERIVATIVES
摘要 <p>Processes for the production of a 32-deoxorapamycin from a 32-iodo- or 32-hydroxyrapamycin, wherein the hydroxy group is substituted by the residue of an arylthionocarbonate or an arylthiocarbamate, in the presence of tris(trimethylsilyl)-silan andα,α′-azo-isobutyronitril in organic solvent; and 32-deoxorapamycin in the form of a crystalline solvate.</p>
申请公布号 EP1979359(A1) 申请公布日期 2008.10.15
申请号 EP20070702931 申请日期 2007.01.22
申请人 NOVARTIS AG 发明人 ACEMOGLU, MURAT;PFEFFER, SABINE
分类号 C07D498/18 主分类号 C07D498/18
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