E.Coli 0157: H7 C1 esterase inhibitor-binding protein STCE and uses thereof

摘要

Disclosed is a p0157 plasmid-specified polypeptide found in E.coli EDL933 and other E. coli that binds to and cleaves C1-esterase inhibitor, and antibodies specific for the polypeptide. Also disclosed are methods employing the polypeptide for diagnosing enterohemorragic E. coli infection, identifying potential inhibitors of its acticity, and reducing viscosity of material containing glycosylated polypeptides.