ПРОИЗВОДНЫЕ БЕНЗОТРОПОЛОНА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ИНГИБИРОВАНИЯ РЕПЛИКАЦИИ ВИРУСОВ И СПОСОБ ЛЕЧЕНИЯ И/ИЛИ ПРОФИЛАКТИКИ БОЛЕЗНЕННЫХ СОСТОЯНИЙ МЛЕКОПИТАЮЩИХ, ВЫЗЫВАЕМЫХ РЕПЛИКИЦИЕЙ ВИРУСОВ, ЭКСПРЕССИРУЮЩИХ МЕТАЛЛОСОДЕРЖАЩИЕ ФЕРМЕНТЫ

摘要

FIELD: chemistry. ^ SUBSTANCE: present invention refers to the new benzotropolone derivatives of general structural formula (A) as well to their pharmaceutically acceptable salts which are able to inhibit the replication of HIV-virus, to pharmaceutical composition thereof and to the method of inhibition of HIV-virus replication. formula (A) where R1 is hydrogen; R2 is OC1-6alkyl; each of R3, R4, R5 independently is hydrogen; G is selected from the group consisting of the structures I, II; R6 is hydrogen; R7 is (CH2)bCOOR9 where b takes up the integer values from 1 to 5; R8 is selected from C1-6alkyls substituted with one or more halogen atoms; W is O; R9 is selected from hydrogen or C1-6alkyl. The structures I, II are represented in the formula of invention. ^ EFFECT: claimed compounds inhibit the replication of HIV-virus. ^ 4 cl, 6 dwg, 7 ex