发明名称 |
NYA 8-ALKYLTIO-2-PIPERAZINO- PYRIMIDO/5,4-D/PYRIMIDINER, DERAS FRAMSTAELLNING OCH DESSA FOERENINGAR INNEHAOLLANDE LAEKEMEDEL. |
摘要 |
The invention relates to new compounds of general formula <IMAGE> (I) wherein R1 represents an alkyl group, R2 represents a hydrogen atom, an alkyl group optionally substituted (except at the alpha carbon atom) by a hydroxy group, or represents a cycloalkyl group or an allyl, phenyl or benzyl group, R3 represents an allyl group, an alkyl group optionally substituted (except at the alpha carbon atom) by a hydroxy group, or represents a cycloalkyl group or R2 and R3 together with the nitrogen atom between them represent a straight-chained alkyleneimino group, the acid addition salts thereof, particularly the acid addition salts thereof with physiologically acceptable inorganic or organic acids which have valuable pharmacological properties, particularly a metastasis-inhibiting effect based on their selective tumour-PDE inhibiting effect, and pharmaceutical compositions containing these compounds or the physiologically acceptable acid addition salts thereof. The new compounds may be prepared according to methods known for analogous compounds. |
申请公布号 |
FI852445(L) |
申请公布日期 |
1985.12.23 |
申请号 |
FI19850002445 |
申请日期 |
1985.06.20 |
申请人 |
DR. KARL THOMAE GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG |
发明人 |
ROCH, JOSEF;HECKEL, ARMIN;NICKL, JOSEF;MUELLER, ERICH;NARR, BERTHOLD;ZIMMERMANN, RAINER;WEISENBERGER, JOHANNES |
分类号 |
A61K31/505;A61K31/55;A61P7/02;A61P9/10;A61P35/00;C07D487/04 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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