摘要 |
The present invention provides for the treatment of primary headache disorders, particularly migraine, using antagonists of the EP<SUB>4 </SUB>receptor for prostaglandin E2. Particular EP<SUB>4 </SUB>receptor antagonists include azole compounds of formula (I): wherein R<SUP>1 </SUP>is a group such as lower alkyl substituted with carboxy; R<SUP>2 </SUP>is hydrogen or lower alkyl, R<SUP>3 </SUP>and R<SUP>4 </SUP>are aryl optionally substituted with halogen, Q is in which -A<SUP>1</SUP>- is a single bond or lower alkylene, is a cyclo group, -A<SUP>3</SUP>- is a single bond or lower alkylene, and X is O, NH or S; or a salt or its solvate thereof.
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