PHARMACEUTICAL COMPOSITION AND PROCESS

摘要

The present invention relates to a method of forming granules of (2R,3S,4R,5R)-5-(4-amino-2-oxo-2 H -pyrimidin-1-yl)-2-azido-3,4-bis -iso-butyryloxy-tetrahydro-furan-2-ylmethyl isobutyrate; hydrochloride salt (I), comprising mixing I, with a granulating amount of a granulating liquid, and a polyethylene glycol (PEG)/polypropylene glycol (PPG) block copolymer as a binder and solubility enhancer to form wet granules which are then dried to remove the granulating liquid.